When’s the best time to get a booster shot? Doctors suggest a six-month interval

whens the best time to get a booster shot doctors suggest a six month interval

Sumary of When’s the best time to get a booster shot? Doctors suggest a six-month interval:

  • Booster shots are rolling out across much of the world to spur protection against Covid-19, prompting questions about when exactly they should be given.
  • It takes time for the immune system to build up its defenses.
  • It takes several months to build what’s known as immune memory — essentially protection galvanized by long-lived, antibody-secreting plasma cells that reside in niches such as the bone marrow.
  • A booster shot given several months after the immune system has been primed by an initial series — usually two doses of the vaccine — can invigorate its response, said Stanley Plotkin, a veteran vaccinologist and emeritus professor of pediatrics at the University of Pennsylvania in Philadelphia.
  • The additional inoculation triggers a surge of antibodies that are more adept at thwarting a range of SARS-CoV-2 variants, he said.
  • An even shorter interval, such as two months, could compromise the body’s ability to establish a durable immune response, he said in an interview.
  • Rest UpThat’s because the immune system needs time to rejuvenate after making antibodies quickly and crudely to a new foe, said John Wherry, director of the institute for immunology at the university’s Perelman School of Medicine.
  • So-called neutralizing antibodies that latch onto coronavirus particles and stop them from penetrating healthy cells are critical in defending against Covid-19. They wane months after immunization or a natural infection, however, increasing the risk of a SARS-CoV-2 infection.

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