Sumary of 8 weeks between shots is the 'sweet spot' for giving Pfizer's two-dose COVID-19 vaccine, UK researchers say:
- A study found that the eight-week delay boosted immune responses higher than waiting 21 days.
- It’s a trade-off between needing two doses and optimizing the immune response, the researchers said.
- Giving the second dose of Pfizer’s two-dose COVID-19 vaccine eight weeks after the first is the “sweet spot” to protect against the fast-spreading Delta variant, a UK research group has said.
- A study posted Friday, led by Oxford University, found that delaying the second dose up to 10 weeks boosted antibodies and “helper” T cells that support the immune system higher than giving it at three weeks, as recommended by Pfizer.
- Two doses of Pfizer’s shot boosted immune responses higher than one dose, no matter the time between doses, the study authors from the universities of Oxford, Newcastle, Liverpool, Sheffield, and Birmingham added.
- A ‘sweet spot’ for protection from the coronavirusSusanna Dunachie, a National Institute for Health Research global research professor at Oxford University who co-led the study, said at a news briefing on Thursday that eight weeks between doses for Pfizer’s vaccine “was the sweet spot.
- ” The study authors cautioned that “regardless of the dosing schedule, the study found levels of antibodies and T cells varied significantly from person to person, which may depend on genetics, underlying health conditions, and past exposure to COVID-19 and other viruses.
- There are risks to delaying the second shotIn the US, the two doses of Pfizer’s vaccine are given at 21 days apart, as recommended by Pfizer.